Postdoctoral Research Opportunity – Hepatic ER Stress and Bile Acid Metabolism and Cholestatic Liver Diseases
The Richard Green Laboratory in the Division of Gastroenterology and Hepatology and Comprehensive Transplant Center at Northwestern University Feinberg School of Medicine is seeking a postdoctoral fellow for an NIH-funded position. Investigations will focus on the role of hepatic ER stress and the unfolded protein response in the regulation of bile acid metabolism and cholestatic liver diseases. Studies will examine the transcriptional regulation of bile acid metabolic genes by hepatic XBP1, FXR, and HNF4alpha signaling pathways. Gene and protein expression and lipid biochemical approaches will determine the resultant effects on cell metabolism. These basic and translational research studies use a range of genetic, cell, and molecular biology, and omics approaches using both in vivo and in vitro models.
This position begins in June 2024 and is available for a minimum of two years with an opportunity for renewal pending satisfactory performance. Salary and benefits are competitive. Applications will be reviewed until the position is filled.
Qualifications for candidates:
- Strong interest and prior record of conducting basic or translational research
- Highly motivated individual with a PhD, MD, or equivalent degree
- Interest in the molecular and cell biology of liver disease pathogenesis and the development of biomarkers and therapeutics
- A minimum of one first-author publication
- Excellent writing and communication skills
- Ability and desire to work in a highly collaborative and transdisciplinary environment
Applications should contain :
- Cover letter
- Statement of research interests, qualifications, and career goals
- Curriculum vitae (including publications list)
- Names and contact information of 3 references
Interested applicants should email their application to Richard M. Green, MD at r-green2@northwestern.edu.