Postdoctoral Training Opportunity – Virology/Neuroscience in the Naghavi Lab
Postdoctoral positions are available on NIH-funded research projects to study the biology of virus infection in different cell types and its links to neurodegeneration, in the Naghavi Lab. Dr. Naghavi is a professor in the department of Microbiology-Immunology at the Northwestern University Feinberg School of Medicine. The Feinberg School is located in the center of downtown Chicago.
Our research focuses on infection by Human Immunodeficiency Virus type 1 (HIV-1), a retrovirus and causative agent of acquired immunodeficiency syndrome (AIDS). In addition to suppressing the immune system, rendering victims susceptible to opportunistic infections, HIV-1 can cross the blood-brain barrier and cause serious damage to the central nervous system, ultimately leading to a broad spectrum of disorders that range from mild impairment to severe HIV-associated dementia.
Our research has had a long-term focus on host factors that regulate HIV-1 infection in a variety of cell types, including microglia and primary neurons. In one area of our research, we have identified specialized microtubule regulators and kinesin adaptor proteins that are exploited by HIV-1 to promote intracellular transport and infection. In a second area of research, we discovered that Amyloid Precursor Protein (APP) is highly expressed in microglia and limits HIV-1 spread; evasion of this restriction by HIV-1 results in the secretion of neurotoxic amyloids. Modulating how APP and HIV-1 interact may provide therapeutic opportunities we are currently exploring. Both projects employ a range of molecular biological approaches, as well as live cell imaging of virus movement and microtubule dynamics in microglia cells.
Candidates must have a PhD or equivalent with strong research experience in virology, neuroscience, and/or molecular biology. Applicants with experience in fluorescence microscopy and live imaging are particularly encouraged to apply. Interested applicants should submit a complete CV, a brief description of their research achievements and interests, and the name and contact details of three referees to Mojgan.Naghavi@Northwestern.edu.
Applications will be reviewed immediately until suitable candidates are identified.