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Postdoctoral Training Opportunity - Neurodegeneration

Two postdoctoral researchers are needed for the Mazzuli Lab, a neuroscience lab at Northwestern University Feinberg School of Medicine, Department of Neurology.

The lab is a basic research lab focused on elucidating the mechanisms of neurodegeneration. Their emphasis is on understanding how amyloid aggregates form in the brain and their downstream toxic functions, such as disrupting protein clearance and lysosomal function. The applicant will be exposed to and learn a variety of techniques ranging from biochemistry, cell biology, and molecular biology, for the characterization of patient-derived neurons generated from induced pluripotent stem cells (iPSC) and mouse models. Their research is concentrated on mechanisms that govern a-synuclein aggregation and how the amyloid forming process results in neurodegeneration in Parkinson’s disease (PD) and other age-related neurodegenerative disorders.

The successful applicant will be expected to lead a portion of a 5 year, NIH-funded research project related to the laboratory’s general field of interest of neurodegeneration. They have two positions available. They are seeking applicants with expertise in using culture or animal models in the analysis of protein aggregation, cell biological assays of the endocytic-lysosomal pathway, glycosphingolipid metabolism, or lysosomal storage diseases. Additionally, applicants with expertise in molecular biology, including transcription regulation, RNA processing and nuclear export, are encouraged to apply. Trainees will develop skills for the study of these pathways at the bench, grant writing, management, and other skills required to eventually gain independence in academia or industry. Ongoing collaborations with the neurology clinic allow for target advancement and translational studies.


Ph.D. degree in cell biology, molecular biology, neuroscience, or biochemistry. Prior cell culture work or experience with culturing human stem cells is required. The applicant must have a demonstrated track record of interest and productivity in neuroscience, neurodegeneration, and/or protein aggregation through previous publications and experience.

COVID-19 Considerations

The lab follows social distancing guidelines as set by the research safety office. All employees are expected to stay 6 feet apart, wash hands regularly, and wear face masks. Supplies such as masks and hand sanitizer are included free of charge.


Interested Candidates should e-mail a single PDF with a cover letter briefly describing their research interests and qualifications, a curriculum vitae, as well as the names and contact information for three references to Dr. Joseph Mazzulli at

Northwestern University is an Equal Opportunity, Affirmative Action Employer of all protected classes, including veterans and individuals with disabilities. Women, underrepresented racial and ethnic minorities, individuals with disabilities, and veterans are encouraged to apply. Hiring is contingent upon eligibility to work in the United States.