Postdoctoral Training Opportunity - OB/GYN, Adli Laboratory
The Adli laboratory at Northwestern University Comprehensive Cancer Center and the Ob/Gyn department is looking for highly talented, motivated, productive, and ambitious postdoctoral fellows (two - three positions open) starting immediately. They need energetic postdocs that have existing experimental skillsets for functional genomics or strong bioinformatics skillsets for computational biology projects. The successful candidates will work on NIH and NSF funded projects on Genome Regulation, Cancer Epigenomics, and High throughout CRISPR screenings for combinatorial drug targets. Please see selected relevant lab publications: Nature Biotechnology, 2014, Nature Methods, 2016, Nature Communications, 2017; Nature Communications 2018; Genome Biology 2018, Cancer Research 2019.
- Perform CRISPR based technologies for targeted as well high throughput genome manipulation
- Perform genome-wide ChIP seq, ATAC-Seq, RNA seq, scRNA-Seq and chromatin conformation, and other cell and animal-based work as needed.
- Integrate big data and cell and animal-based studies for biologic outcome analysis
- Perform literature reviews and draft and edit manuscripts and present data in written and oral form to local and national audiences
- Generate preliminary data and help PI with Grant writing as needed
Their Goal: They aim to discover and target key drivers to cure cancers. To achieve this, they combine their expertise in epigenome mapping with CRISPR based genome manipulations. Their ultimate goal is to understand how human genome is differentially regulated in cancer settings. Their ultimate goal is to reveal and target critical drivers of diseases with a specific focus on cancer.
The lab has strong expertise in CRISPR technologies (Nature Communications 2018; Nature Methods 2016; Nature Biotechnology 2014; NAR, 2015). They are also developing and utilizing novel CRISPR tools to edit the genome, manipulate epigenome, and image live cells chromatin dynamics in living cells (Nature Methods, 2017, Nature Communications, 2017). These functional genomic tools, combined with their capacity to analyze and integrate large-scale data analysis (Genome Biology, 2018) enables them to explore novel ideas and make groundbreaking discoveries. They apply state of the art functional genomics and epigenomics technologies such as ChIP-Seq and RNA-Seq (Cell, 2013, Cancer Cell, 2013) and ATAC-Seq and CRISPR screenings tools (Nature Communications, 2018).
Minimum Qualifications: (Education, experience, and any other certifications or clearances)
- Ph.D. in Molecular Biology, Biochemistry, Cell Biology, and Genomics & Epigenomics
Minimum Competencies: (Skills, knowledge, and abilities.)
- Strong verbal and written communication skills in English
- Ability to efficiently draft manuscripts for fast-paced publication of results
- Ability to multitask and manage multiple ongoing projects simultaneously
- Ability to work independently and as part of a team
- Experience in the isolation and processing of primary human tissues and cells for further molecular and genome-wide analysis
Preferred Qualifications: (Education and experience)
- Ph.D, MD, or MD-Ph.D with a maximum of two years since the degree
Preferred Competencies: (Skills, knowledge, and abilities)
- Cancer epigenomics, bioinformatics, mouse work, Genome-wide assays, and analysis.
Please send a current CV, cover letter stating your interest, and contact information for references to:
Mazhar Adli, PhD, mazhar.adli@northwestern.edu